HIV/AIDS Pathogenesis
Cultured myeloid dendritic cells from HIV patients fail to differentiate
Published in Virus Weekly, August 23rd, 2005
"Current immunological opinion holds that myeloid dendritic cell (mDC) precursors migrate from the blood to the tissues, where they differentiate into immature dermal-and Langerhans-type dendritic cells (DC).
"Tissue DC require appropriate signals from pathogens or inflammatory cytokines to mature and migrate to secondary lymphoid tissue," scientists in England report.
"We show that purified blood mDC cultured in vitro with GM-CSF and IL-4, but in the absence of added exogenous maturation stimuli, rapidly differentiate into two maturational and...
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Source: Virus Weekly (2005-08-23)
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