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Virus Weekly

Susan Hasty, Publisher

Table of Contents . . . May 23rd, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Virus Weekly | Other Publications

Hepatitis C Virus - HCV-like particle assembly requires core protein cleavage

Human Papillomavirus Vaccine - HPV-16 capsomeres plus adjuvant elicits increased vaginal Ig levels

Parainfluenza Vaccine - Attenuated and effective human parainfluenza virus type-1 vaccines developed

Rotavirus Vaccine - Maternal antibodies enhance and suppress B cell responses to rotavirus vaccine

West Nile Virus - Commercial assays for detecting West Nile virus antigen compared

Adenoviral Vector - Replication properties of human adenovirus in different animal species described

Apoptosis - Findings from Australia, Germany and Italy describe new data in apoptosis research

Autoimmune Hepatitis - Autoimmune hepatitis development is influenced by genetic background

Avian Influenza - Rapid response stockpile of Tamiflu now ready and available to the World Health Organization

Avian Influenza Epidemiology - Avian influenza isolated from migratory waterfowl in Germany

Awards - Dynavax Chief Scientific Officer, Robert L. Coffman, PhD, elected to National Academy of Sciences

Business & Finance - Dynavax announces slight increase in first-quarter revenue, provides performance update

Business & Finance - InterMune announces first quarter net loss of $12.8M

Business Update - Software program launched sequences proteins linked to influenza viruses

Cancer Gene Therapy - Adenovirus-mediated gene delivery inhibits nasopharyngeal tumor growth

Cancer Gene Therapy - Antitumor prodrug gene therapy is enhanced using a low Km cyclophosphamide

Cancer Gene Therapy - Mesenchymal progenitor cells deliver oncolytic adenoviruses

Cancer Gene Therapy - Prostate cancer can be treated via adenovirus combination therapy

Cancer Research - Data from South Korea and Germany advance knowledge in cancer research

Cancer Research - Recent studies from the United States add new data to cancer research

Cancer Research - Reports from Japan, Germany and the United States advance knowledge in cancer research

Cancer Research - Reports from Japan, the Netherlands; cjlm and Australia add new data to cancer research

Cancer Research - Reports from Taiwan and the United States describe recent advances in cancer research

Cancer Research - Studies from Netherlands, United States and Germany describe new findings in cancer research

Cancer Therapy - Dual ovarian cancer therapy is achieved using measles virus

Cancer Therapy - New first-line therapy recommended for patients with AIDS-related lymphoma

Cancer Treatment - Findings from the United States and Japan advance knowledge in cancer treatment research

Cardiology - Angiogenic suicide gene cell therapy regulates the effect of angiogenesis in infarcted hearts

Cardiology - Researchers from Germany and the United States report recent findings in cardiology

Cell Biology - Reports from the United Kingdom and United States add new data to cell biology research

Cervical Cancer - Cervical lesion grade linked to p16(INK4A) expression

Cervical Cancer - Researchers' data from the People's Republic of China, United Kingdom and Sweden advance cervical cancer research

Cirrhosis - Researchers from Italy, the United States and Poland publish new studies and findings in the area of cirrhosis

Clinical Trials - Phase II ANA380 dosing shows robust activity against lamivudine-resistant hepatitis B virus

Clinical Trials - Positive interim data reported from trials of interferon enhancer in HCV-I nonresponders

Clinical Trials - Positive trial data reported for HPV therapeutic vaccine in precancerous cervical lesions

Coronavirus Vaccine - Neurovirulent human coronavirus recovered from infectious cDNA clone

Cryptococcosis - Cryptococcosis presentation compared in immunocompetent and nonimmunocompetent patients

Cytomegalovirus Transmission - Cytomegalovirus infection transmission in infants via breast milk reviewed

Cytomegalovirus Vaccine - Rhesus cytomegalovirus homologue of human cytomegalovirus lower matrix phosphoprotein characterized

Dengue Virus Vaccine - Polytopic vaccination modifies immunological response to dengue fever

Diabetes Research - Diabetic mouse model reveals COMP-angiopoietin-1 promotes wound healing

Diagnostics - Peptide mimotopes sensitive and specific for diagnosis of Epstein-Barr virus

Diagnostics - Three human herpesviruses simultaneously detected by multiplex PCR-based DNA array

Drug Development - Alnylam presents phase I data for ALN-RSV01

Drug Development - Biolex Therapeutics announces positive phase I results for hepatitis C drug candidate Locteron

Drug Development - E.U. label change for INTRON A incorporates long-term efficacy data in chronic hepatitis C

Endogenous Retrovirus Pathogenesis - Transgenic mice susceptible to porcine endogenous retrovirus

Epidemiology - Human and animal enteric caliciviruses detected in oysters from various U.S. coastal areas

Epidemiology - West Nile virus persists in Southern California by three mechanisms

Epstein-Barr Virus - Researchers' data from Germany, the United States and Sweden advance Epstein-Barr virus research

Epstein-Barr Virus & Nephropathy - Systemic Epstein-Barr virus infection associated with membranous nephropathy in children

Feline Immunodeficiency Virus Pathogenesis - Soluble CD134 activates feline immunodeficiency virus Env for CXCR4-dependent entry

Finance - Quigley Corporation reports Q1 2006 net sales of $10.3 million compared to $11.8 a year ago

Geriatrics - Somatic gene transfer of CREB attenuates memory impairment in aging rats

HIV/AIDS - Data from the United States and Italy advance knowledge in HIV/AIDS research

HIV/AIDS - Findings from France and the United States in HIV/AIDS provide new insights

HIV/AIDS - Findings from Spain, the South Africa and Ethiopia advance knowledge in HIV/AIDS research

HIV/AIDS - Findings from the United Kingdom and United States advance knowledge in HIV/AIDS research

HIV/AIDS - Findings from the United States describe new data in HIV/AIDS research

HIV/AIDS - New data from the United States lluminates research in HIV/AIDS

HIV/AIDS - New data from the United States, Switzerland and Canada lluminates research in HIV/AIDS

HIV/AIDS - New findings from France, Switzerland and the United States in the area of HIV/AIDS described

HIV/AIDS - New findings from Netherlands and United States in the area of HIV/AIDS described

HIV/AIDS - New findings in HIV/AIDS described from the United States, Spain and United Kingdom

HIV/AIDS - New research from the United States and Belgium in the area of HIV/AIDS detailed

HIV/AIDS - Recent findings from Japan and the United States illuminate research in HIV/AIDS

HIV/AIDS - Recent findings from the United States and Canada illuminate research in HIV/AIDS

HIV/AIDS - Recent findings from the United States illuminate research in HIV/AIDS

HIV/AIDS - Recent findings in HIV/AIDS described by researchers from Denmark and the United States

HIV/AIDS - Recent findings in HIV/AIDS described by researchers from the United States and Germany

HIV/AIDS - Recent findings in HIV/AIDS described by researchers from the United States, Spain and Switzerland

HIV/AIDS - Reports from South Africa and United States advance knowledge in HIV/AIDS research

HIV/AIDS - Reports from the United Kingdom advance knowledge in HIV/AIDS research

HIV/AIDS - Reports from the United States add new data to HIV/AIDS research

HIV/AIDS - Reports from the United States and Canada add new data to HIV/AIDS research

HIV/AIDS - Research from Ireland and the United States in HIV/AIDS provides new insights

HIV/AIDS - Research from Spain and Netherlands in HIV/AIDS provides new insights

HIV/AIDS - Research from the United States and Denmark add new data to HIV/AIDS body of knowledge

HIV/AIDS - Researchers from Italy, the United Kingdom and the United States report details of new studies and findings in the area of HIV/AIDS

HIV/AIDS - Researchers from Japan, the United States and Russia report recent findings in HIV/AIDS

HIV/AIDS - Researchers from the United States and France provide details of new studies and findings in the area of HIV/AIDS

HIV/AIDS - Researchers from the United States and Germany describe findings in HIV/AIDS studies

HIV/AIDS - Researchers from the United States and Greece describe findings in HIV/AIDS studies

HIV/AIDS - Researchers from Zimbabwe, India and the United States publish new studies and findings in the area of HIV/AIDS

HIV/AIDS - Researchers' findings from the United States advance HIV/AIDS research

HIV/AIDS - Researchers' findings from the United States, Germany and France advance HIV/AIDS research

HIV/AIDS - Studies from Japan, Austria and the United States advance knowledge in HIV/AIDS research

HIV/AIDS Assessment - Sign and Symptom Check-List for persons with HIV disease evaluates symptom status

HIV/AIDS Cognition - Caudate blood flow and volume reduced in neurocognitively impaired HIV/AIDS patients

HIV/AIDS Diet & Nutrition - HIV-related diarrhea managed by dietary intervention

HIV/AIDS Drug Development - HIV TAR-Tat inhibited by neamine derivatives

HIV/AIDS Drug Development - HIV-1 replication inhibited by artificial transcription factors targeting primer binding site

HIV/AIDS Drug Development - Oxindole inhibits HIV-1 reverse transcriptase

HIV/AIDS Drug Development - Oxindoles inhibit wild-type and drug-resistant mutant HIV

HIV/AIDS Drug Monitoring - Intraindividual variability in HAART levels limit therapeutic drug monitoring utility

HIV/AIDS Drug Monitoring - Tipranavir plasma levels monitored by high performance liquid chromatography

HIV/AIDS Epidemiology - Current trends in Rwanda's HIV/AIDS epidemic reviewed

HIV/AIDS Epidemiology - HIV/AIDS epidemic in Ethiopia expanding in rural areas

HIV/AIDS Genetics & Genomics - Chromosome 2 carries a gene required for production of infectious HIV-1

HIV/AIDS Immune Response - Pneumococcal vaccine immunogenicity in HIV/AIDS not altered by vitamin A or zinc supplement

HIV/AIDS Knowledge - HIV/AIDS transmission and prevention knowledge low among Nepalese adolescents

HIV/AIDS Neurological Complications - Incidence of neurological complications in AIDS patients receiving HAART determined

HIV/AIDS Neurology - HIV in CSF during early infection not associated with neurological deterioration

HIV/AIDS Neuropathy - Leg epidermal nerve fiber density related to symptomatic distal sensory neuropathy in HIV/AIDS

HIV/AIDS Neuropsychology - Cerebral metabolite changes measure cerebral health in HIV-infected children

HIV/AIDS Patient Care - HIV/AIDS educational workshop improves knowledge and patient attitude among nurses

HIV/AIDS Proteomics - Acetylated Tat regulates HIV-1 splicing via interaction with splicing regulator p32

HIV/AIDS Research - International study investigates the early biology of HIV infection

HIV/AIDS Testing - Following U.S. CDC recommendations on routine HIV testing unveils undiagnosed cases

HIV/AIDS Testing - Undiagnosed HIV patients are fueling continued epidemic in the U.S.

HIV/AIDS Vaccine - Delayed-type hypersensitivity can monitor reactions to HIV-1 vaccine

HIV/AIDS Vaccine - DNA prime/protein boost immunizes against HIV clade C

HIV/AIDS Vaccine - DNA priming and adenovirus boosting reduces viral loads in macaque SIV model

HIV/AIDS Vaccine - HIV partial efficacy vaccines have low acceptability among high-risk communities

HIV/AIDS Vaccine - Progress toward carbohydrate-based HIV-1 vaccine reported

HIV/AIDS-Related Cardiovascular Risk Factors - Cardiovascular risk increased in HIV/AIDS without clustering of metabolic risk variables

HIV/AIDS-Related Encephalitis - Alcohol abuse enhances neuroinflammation and impairs immune response in HIV encephalitis

Hepatitis B Therapy - Chronic hepatitis B seroconversion is better achieved with pegylated interferon alpha-2a

Hepatitis B Therapy - Pradefovir study data drug could become a leading product for the treatment of hepatitis B

Hepatitis B Vaccine - Oxxon Therapeutics HI-8 HBV therapeutic vaccine proves safe and efficacious for chronic hepatitis B

Hepatitis B Virus - Data from Japan, India and the People's Republic of China advance knowledge in hepatitis B virus research

Hepatitis B Virus - HBV replication is inhibited by pyrimidines bearing an acyclic moiety

Hepatitis B Virus - Hepatitis B and delta virus share common hepatocyte entry step

Hepatitis B Virus - Hepatitis B or C infections do not influence hepatocyte CD14 secretion

Hepatitis B Virus - Hepatitis B virus is treatable prophylactically after liver transplantation

Hepatitis B Virus - Hepatitis B virus vaccine response is not linked to mode of dialysis

Hepatitis B Virus - Reports from India, the South Korea and the People's Republic of China describe recent advances in hepatitis B virus research

Hepatitis B Virus - Researchers from Japan, France and the People's Republic of China describe findings in hepatitis B virus studies

Hepatitis C Therapy - Hepatitis C virus replication is inhibited by cyclosporin DEBIO-025 in vitro

Hepatitis C Therapy - Hepatitis C virus-induced inhibition of interferon signaling can be corrected

Hepatitis C Therapy - Higher-dose ribavirin tablets approved in Netherlands; first step to European availability

Hepatitis C Therapy - Novelos Therapeutics IND for novel hepatitis C drug accepted by U.S. FDA

Hepatitis C Therapy - OctoPlus completes Locteron phase I study, presents positive results

Hepatitis C Virus - Alpha-glucosidase inhibitors restrict binding properties of HCV-like particles

Hepatitis C Virus - Chronic HCV infection risks for steatosis and progression of fibrosis clarified

Hepatitis C Virus - Findings from Israel, Italy and Spain in hepatitis C virus provide new insights

Hepatitis C Virus - HCV core protein enhances the immunogenicity of co-delivered DNA vaccine

Hepatitis C Virus - HCV in hemodialysis patients is linked to decreased plasma oxidative load

Hepatitis C Virus - Hepatitis C virus fibrosis progression correlates with serum markers of fibrosis

Hepatitis C Virus - Hepatitis C virus infection influences glomerulonephritis in renal allografts

Hepatitis C Virus - Hepatitis C virus RNA-dependent RNA polymerase inhibitors identified

Hepatitis C Virus - New data from France and Russia lluminates research in hepatitis C virus

Hepatitis C Virus - Occult hepatitis C virus infection is affected by anti-viral therapy

Hepatitis C Virus - Research from Canada and Japan in hepatitis C virus provides new insights

Hepatitis C Virus - Researchers from Spain and Germany publish new studies and findings in the area of hepatitis C virus

Hepatitis C Virus - Researchers' findings from Switzerland, the South Korea and the United States advance hepatitis C virus research

Hepatocellular Carcinoma - Findings from the People's Republic of China, Taiwan and United States in hepatocellular carcinoma provide new insights

Hepatocellular Carcinoma - HCC tumor-associated antigen and antibody response can be identified in patients

Hepatocellular Carcinoma - Hepatocellular carcinoma with hepatitis C patients benefit from limited hepatic resection

Hepatocellular Carcinoma - Recent findings in hepatocellular carcinoma described by researchers from Japan and the United States

Hepatocellular Carcinoma - Researchers from the United States, Japan and Italy provide details of new studies and findings in the area of hepatocellular carcinoma

Herpes - New findings in herpes described from the United States

Herpes - Reports from the United States and Japan describe recent advances in herpes research

Human Papillomavirus Vaccine - Incidence of high-risk HPV types is low among HIV-infected pregnant Thai women

Human Papillomavirus Vaccine - Unmethylated CpG ODN inhibit HPV16-associated tumors

Imaging - New findings in imaging described from South Korea and Germany

Infectious Diseases - Human metapneumovirus has presentation and outcomes similar to respiratory syncytial virus

Influenza - Findings from Netherlands, Australia and Finland describe new data in influenza research

Influenza A Vaccine - Inactivated subvirion influenza A vaccine appears immunogenic

Influenza Vaccine - Inactivated nasal influenza vaccine safe and immunogenic in healthy adults

Influenza Vaccine - Influenza vaccine effectiveness low among non-institutionalized elderly in Japan

Influenza Vaccine - Intramuscular injection required to optimize influenza vaccination in elderly

Influenza Vaccine - Intranasal influenza vaccine proves more effective than injectable form in children

Kaposi Sarcoma-Associated Herpesvirus - HSHV LANA modulates K1 expression through its cis-acting elements within terminal repeats

Liver Cancer - Research from the United States and Germany in liver cancer provides new insights

Liver Disease - Hepatitis B- and C-related liver cirrhosis may involve similar roles for oval cells

Liver Diseases - NASH and hepatitis C produce similar and different cirrhosis outcomes

Malaria - Medical Services International completes testing on malaria diagnostic kit

Marketing - Peregrine Pharmaceuticals transitions Tarvacin name to official generic name bavituximab

Marketing - Tm Bioscience signs regional distributor to sell respiratory viral panel in Turkey

Measles Vaccine - Measles immunity and immunization status in Australian children reported

Medical Devices - Aethlon Medical completes human safety study

Mergers & Acquisitions - Dynavax closes acquisition of Rhein Biotech GmbH from Crucell

Neonatal Ocular Herpes Infection - Genital herpes epidemic likely to cause increase in neonatal ocular herpes

Neurology - Findings from Germany, Italy and the United States in neurology provide new insights

Norovirus - Studies from Australia, Finland and the United States describe new findings in norovirus research

Obstetrics - Researchers from Greece, the Korea; hskwon@ildong and the South Korea report details of new studies and findings in the area of obstetrics

Papillomavirus - Findings from the United States in papillomavirus provide new insights

Parainfluenza Vaccine - Live parainfluenza type 3 virus vaccine in children reviewed

Polio - Reports from South Africa, United States and Japan describe recent advances in polio research

Polyoma BK Virus Therapy - Renal allograft polyoma BK virus infection safely and effectively treated by leflunomide

Poxvirus Outbreaks - Fatal poxvirus outbreak identified in New World monkey colony in Germany

Proteomics - Human herpesvirus 6 U94/REP protein inhibits betaherpesvirus replication

Respiratory System - Findings from Uruguay and Argentina describe new data in respiratory system research

Rift Valley Fever Virus - Infectious Rift Valley fever virus rescued from cDNA

Rotavirus Diarrhea - One in 52 children hospitalized for rotavirus diarrhea in New Zealand by age 3

SARS - Findings from Taiwan and the United Kingdom in SARS provide new insights

SARS - Researchers from Netherlands, Taiwan and Canada report details of new studies and findings in the area of SARS

SARS - SARS scoring system effectively screens patients during outbreaks

Sexually Transmitted Disease Prevention - Biologically based health instruction teaches adolescents about STD transmission

Simian Immunodeficiency Syndrome Pathogenesis - Th-1-type CD8+ responses to SIV are consistent feature of natural SIV infection

Smallpox Vaccine - IMVAMUNE is promising candidate as third generation smallpox vaccine

Squamous Cell Carcinoma - HPV16 E7 epitope-specific T cells found in squamous cell carcinoma of the oropharynx

Steatohepatitis - COX-2 is induced in mice with experimental nutritional steatohepatitis

Transplantation Biology - Risk factors identified for diabetes mellitus in renal transplant recipients

Transplants - Recent studies from Turkey, Germany and Japan add new data to transplants research

Transplants - Reports from Japan, Sweden and Brazil add new data to transplants research

Transplants - Researchers' data from Germany, Iran and the United States advance transplants research

Transplants - Researchers' work from the United States and Spain adds to transplants body of knowledge

Type 1 Diabetes - Type 1 immune response against Coxsackie virus B4 is lower in children with type 1 diabetes

Vaccine Vector - Plasmid DNA sequences herpes virus amplicon vectors cause rapid transgene silencing

Vaccines - Recent studies from the United States, Germany and Russia add new data to vaccines research

Vaccines - Reports from the United States describe recent advances in vaccines research

Vaccinia Virus - Findings from Taiwan and the United States describe new data in vaccinia virus research

Vector Development - Peptide insertion library allows enhanced purification of retroviral and lentiviral vectors

Virology - Dengue virus resistance engineered in genetically modified Aedes aegypti

Virology - Researchers from the United States and Brazil report details of new studies and findings in the area of virology

West Nile Virus - West Nile virus quantified in Culex species in southern U.S.

West Nile Virus Pathogenesis - West Nile virus replicates in equine monocytes

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