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Human Papillomavirus Vaccine

HPV-16 capsomeres plus adjuvant elicits increased vaginal Ig levels

Published in Virus Weekly, May 23rd, 2006

Intranasal immunization with human papillomavirus type 16 capsomeres in the presence of non-toxic cholera toxin-based adjuvants elicits increased vaginal immunoglobulin levels.

According to a study from Germany, "Prophylactic immunization against human papillomaviruses (HPVs) aims preferentially at the generation of antibodies, which are directed against the virus capsid proteins. DNA-free virus-like particles or their pentameric subunits, the capsomeres represent suitable antigens. Here we investigated if anti-HPV16 L1 specific antibodies and U-specific CTL induced by intranasal immunization with capsomeres in sera and vaginal washings of C57B16 mice can be enhanced by...

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