Parainfluenza Vaccine

Attenuated and effective human parainfluenza virus type-1 vaccines developed

Published in Virus Weekly, May 23rd, 2006

Attenuated and effective human parainfluenza virus type-1 vaccine candidates were generated by reverse genetics.

According to recent research from the United States, "The P/C gene of human parainfluenza virus type 1 (HPIV1) encodes a nested set of related accessory C proteins, C'/C/Y1/Y2, which have been shown in other paramyxoviruses to have a role in evasion of the type I interferon (IFN) response following virus infection.

"We previously demonstrated that a set of two amino acid substitutions, C-R84G/HNT553A, and a separate amino acid substitution, C-F170S, are independently attenuating for HPIV1 in African green monkeys (AGMs). However, in each...

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Source: Virus Weekly (2006-05-23)

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