Rotavirus Vaccine

Maternal antibodies enhance and suppress B cell responses to rotavirus vaccine

Published in Virus Weekly, May 23rd, 2006

Low titer maternal antibodies can both enhance and suppress B cell responses to a combined live attenuated human rotavirus and VLP-ISCOM vaccine.

According to recent research from the United States, Canada, and Sweden, "We investigated effects of low titer (Lo) circulating MatAb on protection and immunogenicity of attenuated (Att) human rotavirus (HRV) priming and 2/6-virus-like particle (VLP)-immunostimulating complex (ISCOM) boosting (AttHRV/VLP) or VLP-ISCOM alone vaccines. LoMatAb had both enhancing and suppressing effects on B cell responses, depending on tissue, antibody isotype and vaccine."

"Differential effects of LoMatAb on IgA responses in...

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Source: Virus Weekly (2006-05-23)

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