Measles Virus Evolution
High substitution rate of measles virus may allow evolution of escape
Published in Virus Weekly, September 5th, 2006
According to a study from England, "RNA viruses have high nucleotide substitution rates, and therefore the potential to mutate rapidly. In the case of vaccine preventable RNA viruses, this may potentially lead to emergence of vaccine escape mutants.
"The WHO has targeted measles virus (MV) for elimination in many regions, and its genetic variability is monitored to estimate appearance of such mutants. Phylogenetic analysis of partial N or H genes of 230 MV strains circulating in the U.K. over a 10-year period was performed."
"Substitution rates in three...
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Source: Virus Weekly (2006-09-05)
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