Virology

Virus invasion of host cells identities a novel role for caveolae

Published in Virus Weekly, November 14th, 2006

According to recently published research from the United States, virus invasion of host cells identities a novel role for caveolae in endosomal sorting of noncaveolar ligands.

"Invasion of glial cells by the human polyomavirus, JC virus (JCV), leads to a rapidly progressing and uniformly fatal demyelinating disease known as progressive multifocal leukoencephalopathy. The endocytic trafficking steps used by JCV to invade cells and initiate infection are not known," wrote W. Querbes and colleagues, Brown University.

They continued, "We demonstrated that JCV infection was inhibited by dominant defective and constitutively active Rab5-GTPase mutants that...

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Source: Virus Weekly (2006-11-14)

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