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Herpes Simplex Virus
Researchers from University of Chicago detail new studies and findings in the area of herpes simplex virus
April 10th, 2007
Researchers detail in "Separation of receptor-binding and profusogenic domains of glycoprotein D of herpes simplex virus 1 into distinct interacting proteins," new data in herpes simplex virus. "The 369-residue glycoprotein D (gD) is the entry, receptor-binding protein of herpes simplex virus 1. The common receptors for viral entry are nectin-1, HveA, and a specific O-linked sulfated proteoglycan," investigators in the United States report. "The major receptor-binding sites of gD are at the N terminus, whereas the domain required for fusion of viral envelope with the plasma membrane is at the C terminus of the ectodomain (residues 260-310). In the course of retargeting...
Source: Virus Weekly (2007-04-10)
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