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JC Virus Immunology
Study results from Beth Israel Deaconess Medical Center, Department of Neurology update understanding of JC virus immunology
April 10th, 2007
New investigation results, "Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy," are detailed in a study published in The Journal of Virology. According to recent research from the United States, "JC virus (JCV)-specific CD8+ cytotoxic T lymphocytes (CTL) are associated with a favorable outcome in patients with progressive multifocal leukoencephalopathy (PML) and cross-recognize the polyomavirus BK virus (BKV). We sought to determine the frequency and phenotype in fresh blood of CD8+ T cells specific for two A*0201-restricted JCV epitopes, VP1(p36) and VP1(p100), and assess their impact...
Source: Virus Weekly (2007-04-10)
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