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Sendai Virus
Study results from National Institute of Infectious Disease, Infectious Diseases Department provide new insights into sendai virus
April 10th, 2007
A report, "Importance of the anti-interferon capacity of Sendai virus C protein for pathogenicity in mice," is newly published data in The Journal of Virology. "The Sendai virus (SeV) C protein blocks signal transduction of interferon (IFN), thereby counteracting the antiviral actions of IFN. Using HeLa cell lines expressing truncated or mutated SeV C proteins, we found that the C-terminal half has anti-IFN capacity, and that K(151)A, E(153)A, and R(154)A substitutions in the C protein eliminated this capacity," researchers in Tokyo, Japan report. "Here, we further created the mutant virus SeV Cm*, in which K(151)A, E(153)K, and R(157)L substitutions in the C...
Source: Virus Weekly (2007-04-10)
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