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Coronavirus Genetics
Researchers from University of Tennessee, Department of Microbiology report details of new studies and findings in the area of coronavirus genetics
April 10th, 2007
Investigators publish new data in the report "5'-proximal hot spot for an inducible positive-to-negative-strand template switch by coronavirus RNA-dependent RNA polymerase." According to recent research published in the Journal of Virology, "Coronaviruses have a positive-strand RNA genome and replicate through the use of a 3' nested set of subgenomic mRNAs each possessing a leader (65 to 90 nucleotides [nt] in length, depending on the viral species) identical to and derived from the genomic leader. One widely supported model for leader acquisition states that a template switch takes place during the generation of negative-strand antileader-containing templates used subsequently for...
Source: Virus Weekly (2007-04-10)
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