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Cytomegalovirus Cell Biology
Recent findings from Washington University, Department of Molecular Microbiology highlight research in cytomegalovirus cell biology
April 10th, 2007
Scientists discuss in "Human cytomegalovirus UL38 protein blocks apoptosis" new findings in cytomegalovirus. "Apoptosis is an innate cellular defense response to viral infection. The slow-replicating human cytomegalovirus (HCMV) blocks premature death of host cells prior to completion of the infection cycle," scientists in the United States report. "In this study, we report that the HCMV UL38 gene encodes a cell death inhibitory protein. A mutant virus lacking the pUL38 coding sequence, ADdlUL38, grew poorly in human fibroblasts, failed to accumulate viral DNA to wild-type levels, and induced excessive death of infected cells. Cells expressing pUL38 were resistant to...
Source: Virus Weekly (2007-04-10)
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