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Carcinoma Cell Biology
Research from Karolinska Institut has provided new information about carcinoma cell biology
August 14th, 2007
Researchers detail in "Epstein-Barr virus-encoded LMP1 promotes cisplatin-induced caspase activation through JNK and NF-kappaB signaling pathways," new data in carcinoma. "Our previous studies have shown that Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) potentiates chemotherapeutic agent-induced apoptosis in human cell lines of epithelial origin: cervical carcinoma-derived HeLa cells and nasopharyngeal carcinoma-derived TW03 cells. LMP1 acted upstream of caspase-dependent mitochondrial perturbation, and the effect was mapped to the C-terminal signaling domain of LMP1, designated CTAR2," scientists in Stockholm, Sweden report. "CTAR2 is known to...
Source: Virus Weekly (2007-08-14)
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