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Cancer Gene Therapy
Data on cancer gene therapy detailed by researchers at Emory University, Winship Cancer Institute
August 14th, 2007
New research, "Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4," is the subject of a report. According to recent research from the United States, "There is a need for novel therapies targeting hypoxic cells in tumors. These cells are associated with tumor resistance to therapy and express hypoxia inducible factor-1 (HIF-1), a transcription factor that mediates metabolic adaptation to hypoxia and activates tumor angiogenesis." "We previously developed an oncolytic adenovirus (HYPR-Ad) for the specific killing of hypoxic/HIF-active tumor cells, which we now armed with an interleukin-4 gene...
Source: Virus Weekly (2007-08-14)
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