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Cancer Gene Therapy
Research on cancer gene therapy published by M.K. Magnusson et al
August 14th, 2007
Data detailed in "Adenovirus 5 vector genetically re-targeted by an Affibody molecule with specificity for tumor antigen HER2/neu" have been presented. According to recent research published in the journal Cancer Gene Therapy, "In order to use adenovirus (Ad) type 5 (Ad5) for cancer gene therapy, Ad needs to be de-targeted from its native receptors and re-targeted to a tumor antigen. A limiting factor for this has been to find a ligand that (i) binds a relevant target, (ii) is able to fold correctly in the reducing environment of the cytoplasm and (iii) when incorporated at an optimal position on the virion results in a virus with a low physical particle to plaque-forming units...
Source: Virus Weekly (2007-08-14)
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