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Chemotherapy
Research from A.G. Artemenko and co-researchers in the area of chemotherapy described
August 14th, 2007
Research findings, "Identification of individual structural fragments of N,N'-(bis-5-nitropyrimidyl)dispirotripiperazine derivatives for cytotoxicity and antiherpetic activity allows the prediction of new highly active compounds," are discussed in a new report. "The objectives of this study were (i) to apply computer-based technologies to evaluate the structure of 48 N,N'-(bis-5-nitropyrimidyl)dispirotripiperazines which belong to a new class of highly active antiviral compounds binding to cell surface heparan sulphates, (ii) to understand the chemical-biological interactions governing their activities, and (iii) to design new compounds with strong antiviral activity. The logarithm of 50%...
Source: Virus Weekly (2007-08-14)
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