Gene Therapy
Reports summarize gene therapy research from Erasmus University, Department of Neurology
Published in Virus Weekly, February 26th, 2008
New research, 'Targeting malignant gliomas with a glial fibrillary acidic protein (GFAP)-selective oncolytic adenovirus,' is the subject of a report. According to recent research from Rotterdam, Netherlands, "Glial fibrillary acidic protein (GFAP) is an intermediate filament protein abundantly expressed in malignant gliomas. We have constructed a novel oncolytic adenovirus, Ad5-gfa2(B)3-E1, for treatment of these tumors."
"In this construct, the E1 region is under control of the tissue-specific GFAP promoter (gfa2) with three additional copies of the glial specific 'B' enhancer. Infection of a GFAP-positive cell line with Ad5-gfa2(B)3-E1 resulted in E1A and E1B...
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Source: Virus Weekly (2008-02-26)
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