Immunodeficiency
New immunodeficiency findings from University of Ulm described
Published in Virus Weekly, March 4th, 2008
"Nef is a multifunctional accessory protein of primate lentiviruses. Recently, it has been shown that the ability of Nef to downmodulate CD4, CD28, and class I major histocompatibility complex is highly conserved between most or all primate lentiviruses, whereas Nef-mediated downregulation of T-cell receptor-CD3 was lost in the lineage that gave rise to human immunodeficiency virus type 1 (HIV-1)," scientists writing in the Journal of Virology report.
"Whether or not other Nef activities are preserved between different groups of primate lentiviruses remained to be determined. Here, we show that nef genes from a large variety of HIVs and simian immunodeficiency...
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Source: Virus Weekly (2008-03-04)
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