Virology

Findings from S. Bottcher and co-authors broaden understanding of virology

Published in Virus Weekly, March 4th, 2008

"Proteins of the capsid proximal tegument are involved in the transport of incoming capsids to the nucleus and secondary envelopment after nuclear egress. Homologs of the essential large capsid proximal tegument protein pUL36 are conserved within the Herpesviridae," investigators in Greifswald, Germany report.

"They interact with another tegument component, pUL37, and contain a deubiquitinating activity in their N termini which, however, is not essential for virus replication. Whereas an internal deletion of 709 amino acids (aa) within the C-terminal half of the alphaherpesvirus pseudorabies virus (PrV) pUL36 does not impair its function (S. Bottcher, B. G. Klupp, H....

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Source: Virus Weekly (2008-03-04)

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