A new study, 'Chronic innate immune activation as a cause of HIV-1 immunopathogenesis,' is now available. "Human immunodeficiencyvirus (HIV)-1 infection causes progressive impairment of the immune system in humans, characterized by depletion of CD4 T cells and loss of T cell function. Increased markers of T cell activation and lymphoidhyperplasia suggest that chronic T cell activation persists in immunocompromised hosts, and contributes to the exhaustion of immune functions," scientists in the United States report.
"Here we propose a revision of this hypothesis, in which we suggest that chronic activation of innate immunity may negatively affect adaptive T...
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