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DNA Research
Study findings on DNA research are outlined in reports from A.W. Thomae and colleagues
May 13th, 2008
According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "In all eukaryotic cells, origins of DNA replication are characterized by the binding of the origin recognition complex (ORC). How ORC is positioned to sites where replication initiates is unknown, because metazoan ORC binds DNA without apparent sequence specificity." "Thus, additional factors might be involved in ORC positioning. Our experiments indicate that a family member of the high-mobility group proteins, HMGA1a, can specifically target ORC to DNA. Coimmunoprecipitations and imaging studies demonstrate that HMGA1a interacts...
Source: Virus Weekly (2008-05-13)
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