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Gene Therapy
Recent studies by A. Doenecke and co-authors add new data to gene therapy findings
May 13th, 2008
" The essential prerequisite for successful gene therapy in vivo is an effective and long-lasting transfer of the desired gene into the respective cell type or tissue. Over the last decades, many different methods have been developed for this purpose," researchers in Regensburg, Germany report. "The use of plasmid DNA seems to be a good alternative to the commonly used viral vectors because its large-scale production is simple, and side effects are low. Unfortunately, most reports describe only short-term expression in vivo, probably due to the lack of genomic integration in the target cell. This problem can possibly be addressed by the use of adeno-associated virus...
Source: Virus Weekly (2008-05-13)
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