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Gene Therapy
Study data from University of California update knowledge of gene therapy
May 13th, 2008
"Insulin- like growth factor I ( IGF- 1) is a pleiotropic growth factor that has been demonstrated to protect against acute ischemic brain injury. Whether IGF- 1 improves long- term functional outcome after ischemic stroke is not known," scientists in the United States report. "The aim of this study is to examine whether IGF- 1 overexpression through adeno- associated virus ( AAV) - mediated gene transfer enhances neurovascular remodeling and improves functional outcome in a mouse model of focal cerebral ischemia. Long- term cerebral IGF- 1 overexpression was achieved with the AAV transduction system through stereotaxic injection. Control mice were injected with AAV - green...
Source: Virus Weekly (2008-05-13)
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