Antivirals

Research from Hokkaido University reveals new findings on antivirals

Published in Virus Weekly, June 3rd, 2008

According to recent research from Sapporo, Japan, "A DExD/H protein, RIG-1, is critical in innate antiviral responses by sensing viral RNA. Here we show that RIG-I recognizes two distinct viral RNA patterns: double-stranded (ds) and 5'ppp single-stranded (ss) RNA."

"The binding of RIG-I with dsRNA or 5'ppp ssRNA in the presence of ATP produces a common structure, as suggested by protease digestion. Further analyses demonstrated that the C-terminal domain of RIG-I (CTD) recognizes these RNA patterns and CTD coincides with the autorepression domain. Structural analysis of CTD by NMR spectroscopy in conjunction with mutagenesis revealed that the basic surface of CTD with a...

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Source: Virus Weekly (2008-06-03)

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