Life Sciences
Recent findings in life sciences described by A. Kieser and colleagues
Published in Virus Weekly, November 11th, 2008
A new study, 'Pursuing different 'TRADDes': TRADD signaling induced by TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1,' is now available. According to recent research from Munchen, Germany, "The pro-apoptotic tumor necrosis factor (TNF)-receptor 1-associated death domain protein (TRADD) was initially identified as the central signaling adapter molecule of TNF-receptor 1 (TNFR1). Upon stimulation with the pro-inflammatory cytokine TNF-alpha, TRADD is recruited to the activated TNFR1 by direct interaction between the death domains of both molecules."
"TRADD mediates TNFR1 activation of NF-kappaB and c-Jun N-terminal kinase (JNK), as well as caspase-dependent...
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Source: Virus Weekly (2008-11-11)
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