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HIV/AIDS
Studies by D. Vanbaarle and co-authors describe new findings in HIV/AIDS
November 25th, 2008
"Individuals infected with human immunodeficiency virus (HIV) have low numbers of functional Epstein-Barr virus (EBV)-specific CD8(+) T cells in the face of a high EBV load, suggesting that these cells have become exhausted," researchers in Netherlands report. "We investigated whether the observed chronic EBV loads during HIV infection could cause exhaustion of EBV-specific T cells by using flow-FISH (flow cytometry in combination with fluorescence in situ hybridization) to analyze the telomere length of EBV-specific CD8(+) T cells. Enhanced telomere shortening of EBV-specific T cells was observed during HIV infection, compared with the decline in telomere length...
Source: Virus Weekly (2008-11-25)
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