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Life Sciences
Researchers from University of Pittsburgh describe findings in life sciences
November 25th, 2008
"Neonatal injection of recombinant adeno-associated virus serotype 8 (rAAV8) vectors results in widespread transduction in multiple organs and therefore holds promise in neonatal gene therapy. On the other hand, insertional mutagenesis causing liver cancer has been implicated in rAAV- mediated neonatal gene transfer," scientists writing in the Journal of Virology report. "Here, to better understand rAAV integration in neonatal livers, we investigated the frequency and spectrum of genomic integration of rAAV8 vectors in the liver following intraperitoneal injection of 2.0 x 10(11) vector genomes at birth. This dose was sufficient to transduce a majority of...
Source: Virus Weekly (2008-11-25)
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