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Respiratory Syncytial Virus
Data from Hokkaido University provide new insights into respiratory syncytial virus
November 25th, 2008
"Monocyte-derived dendritic cells (mDCs) recognize viral RNA extrinsically by Toll-like receptor (TLR)3 on the membrane and intrinsically retinoic acid-inducible on the membrane and intrinsically retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5) in the cytoplasm to induce type I IFNs and mDC maturation. When mDCs were treated with live or UV-irradiated respiratory syncytial virus (RSV), early (similar to 4h) induction of IFN-beta usually occurs in other virus infections was barely observed," scientists in Sapporo, Japan report. "Live RSV subsequently replicated to activate the cytoplasmic IFN-inducing pathway leading to robust type...
Source: Virus Weekly (2008-11-25)
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