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Epstein-Barr Virus
Scientists at Russian Academy of Medical Science describe research in Epstein-Barr virus
November 25th, 2008
Investigators publish new data in the report 'Functionally significant mutations in the Epstein-Barr virus LMP1 gene and their role in activation of cell signaling pathways.' "Latent membrane protein 1 (LMP1) of the Epstein-Barr virus is a constitutively activated analog of the tumor necrosis factor receptor TNF-R1. LMP1 serves as a viral oncogene able to transform human B-lymphocytes and rodent fibroblasts via activation of numerous cellular signal cascades," scientists writing in the journal Biochemistry report. "Two specific motifs within LMP1 are responsible for interaction of this viral protein with the receptor protein beta-TrCP/HOS SCF of the ubiquitin...
Source: Virus Weekly (2008-11-25)
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