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Bioengineering
Research reports from University of Minnesota provide new insights into bioengineering
November 25th, 2008
According to a study from the United States, "APOBEC3G limits the replication of human immunodeficiency virus type 1, other retroviruses, and retro-transposons. It localizes predominantly to the cytoplasm of cells, which is consistent with a model wherein cytosolic APOBEC3G packages into assembling virions, where it exerts its antiviral effect by deaminating viral cDNA cytosines during reverse transcription." "To define the domains of APOBEC3G that determine cytoplasmic localization, comparisons were made with APOBEC3B, which is predominantly nuclear. APOBEC3G/APOBEC3B chimeric proteins mapped a primary subcellular localization determinant to a region within the first...
Source: Virus Weekly (2008-11-25)
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