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Cytomegalovirus
Research on cytomegalovirus detailed by J.Y. Zhang and co-authors
November 25th, 2008
"Attrition of heterologous virus-specific CD8(+) T cells has been demonstrated in murine viral infection; however, little is known regarding this phenomenon in human viral infections. In this study, we observed that CMV-specific CD8(+) T cells displayed numerical decline and functional impairment in the early phase of acute infection, whereas programmed death-1 (PD-1) expression was significantly up-regulated by these CMV-specific CD8(+) T cells," scientists writing in the Journal of Immunology report. "This early PD-1 up-regulation was found to be closely associated with the increased apoptotic sensitivity of CW-specific CD8(+) T cells. The in vitro addition of...
Source: Virus Weekly (2008-11-25)
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