Epstein-Barr Virus
New Epstein-Barr virus study findings have been published by scientists at Yale University
Published in Virus Weekly, February 10th, 2009
According to a study from the United States, "ZEBRA, a transcription factor and DNA replication protein encoded by the Epstein-Barr Virus (EBV) BZLF1 gene, plays indispensable roles in the EBV lyric cycle. We recently described the phenotypes of 46 single amino acid substitutions introduced into the DNA-recognition region of ZEBRA [Heston, L., El-Guindy A., Countryman, J., Dela Cruz, C., Delecluse, H.J., and Miller, G. 2006]."
"The 27 DNA-binding-proficient mutants exhibited distinct defects in their ability to activate expression of the kinetic classes of viral genes. Four phenotypic variants Could be discerned: wild-type, defective at activating Rta, defective at...
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Source: Virus Weekly (2009-02-10)
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