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Acute Hepatitis
Reports outline acute hepatitis study results from University of Ulm
June 16th, 2009
According to a study from Ulm, Germany, "Coinhibitors and costimulators control intrahepatic T cell responses that trigger acute hepatitis. We used the ConA-induced hepatitis model in the mouse to test if the coinhibitor herpes virus entry mediator (HVEM) modulates hepatitis-inducing T cell responses." "Compared with ConA-injected, wild-type (wt) C57BL/6 (116) mice, HVEM-deficient (HVEM-/-) B6 mice showed lower serum transaminase levels and lower proinflammatory IFN-gamma, but higher protective IL-22 serum levels and an attenuated liver histopathology. The liver type I invariant NKT cell population that initiates acute hepatitis in this model was reduced in HVEM-/- mice...
Source: Virus Weekly (2009-06-16)
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