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Adenovirus
New adenovirus study results from Cornell University described
June 16th, 2009
According to a study from the United States, "Pathogen recognition is a critical function of immune sentinel cells. Nave macrophages or dendritic cells (DCs) undergo pathogen-directed activation and maturation, and as mature antigen-presenting cells (APCs), they contribute essential functions to both innate and adaptive immunity." "Using recombinant adenovirus (rAdV) as a model for murine APC activation by DNA viruses, we demonstrate a critical role for stress kinase activation in cell intrinsic and extrinsic antiviral signaling cascades. We propose two viral triggers, viral capsid and viral DNA, are required for APC activation. Endosomal escape and presentation of...
Source: Virus Weekly (2009-06-16)
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