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Epstein-Barr Virus
New Epstein-Barr virus data have been reported by B. Neuhierl and co-authors
June 16th, 2009
"Epstein-Barr virus (EBV) infection is mediated by several viral envelope glycoproteins. We have assessed gp110's functions during the virus life cycle using a mutant that lacks BALF4 (Delta BALF4)," scientists writing in the Journal of Virology report. "Exposure of various cell lines and primary cell samples of epithelial or lymphoid lineages to the Delta BALF4 mutant failed to establish stable infections. The Delta BALF4 virus, however, did not differ from wild-type EBV in its ability to bind and become internalized into primary B cells, in which it elicited a potent T-cell-specific immune reaction against virion constituents. These findings show that Delta...
Source: Virus Weekly (2009-06-16)
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