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Gene Therapy
Findings from E. Henckaerts et al in gene therapy reported
July 7th, 2009
According to recent research from London, the United Kingdom, "A variety of viruses establish latency by integrating their genome into the host genome. The integration event generally occurs in a nonspecific manner, precluding the prediction of functional consequences from resulting disruptions of affected host genes." "The nonpathogenic adeno-associated virus (AAV) is unique in its ability to stably integrate in a site-specific manner into the human MBS85 gene. To gain a better understanding of the integration mechanism and the consequences of MBS85 disruption, we analyzed the molecular structure of AAV integrants in various latently infected human cell lines. Our...
Source: Virus Weekly (2009-07-07)
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