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DNA Research
New findings reported from M. Fragkos and co-authors describe advances in DNA research
July 7th, 2009
"Phosphorylation of H2AX (gamma H2AX) is an early sign of DNA damage induced by replication stalling. However, the role of H2AX in the repair of this type of DNA damage is still unclear," scientists writing in the journal Molecular and Cellular Biology report. "In this study, we used an inactivated adeno-associated virus (AAV) to induce a stalled replication fork signal and investigate the function of gamma H2AX. The cellular response to AAV provides a unique model to study gamma H2AX function, because the infection causes pannuclear H2AX phosphorylation without any signs of damage to the host genome. We found that pannuclear gamma H2AX formation is a result of...
Source: Virus Weekly (2009-07-07)
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