Life Sciences

Data from B.C. Beard and colleagues advance knowledge in life sciences

Published in Virus Weekly, July 14th, 2009

"Overexpression of methylguanine methyltransferase P140K (MGMTP140K) has been successfully used for in vivo selection and chemoprotection in mouse and large animal studies, and has promise for autologous and allogeneic gene therapy. We examined the long-term safety of MGMTP140K selection in a clinically relevant dog model," scientists in the United States report.

"Based on the association of provirus integration and protooncogene activation leading to leukemia in the X-linked immunodeficiency trial, we focused our analysis on the distribution of retrovirus integration sites (RIS) relative to proto-oncogene transcription start sites (TSS). We analyzed RIS near...

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Source: Virus Weekly (2009-07-14)

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