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Respiratory Syncytial Virus
New research on respiratory syncytial virus from Monash University summarized
July 14th, 2009
According to recent research published in the Journal of Virology, "The respiratory syncytial virus (RSV) matrix ( M) protein is localized in the nucleus of infected cells early in infection but is mostly cytoplasmic late in infection. We have previously shown that M localizes in the nucleus through the action of the importin beta 1 nuclear import receptor." "Here, we establish for the first time that M's ability to shuttle to the cytoplasm is due to the action of the nuclear export receptor Crm1, as shown in infected cells, and in cells transfected to express green fluorescent protein (GFP)-M fusion proteins. Specific inhibition of Crm1-mediated nuclear export...
Source: Virus Weekly (2009-07-14)
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