HIV/AIDS

Report summarizes HIV/AIDS study findings from A.N. Harman and co-researchers

Published in Virus Weekly, August 25th, 2009

According to recent research from Westmead, Australia, "Dendritic cells (DCs) play a key role in the pathogenesis of HIV infection. HIV interacts with these cells through 2 pathways in 2 temporal phases, initially via endocytosis and then via de novo replication."

"Here the transcriptional response of human DCs to HIV-1 was studied in these phases and at different stages of the virus replication cycle using purified HIV-1 envelope proteins, and inactivated and viable HIV-1. No differential gene expression was detected in response to envelope. However, more than 100 genes were differentially expressed in response to entry of viable and inactivated HIV-1 in the first...

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Source: Virus Weekly (2009-08-25)

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