Hemophagocytic Lymphohistiocytosis

Study findings from J.A. Bird et al provide new insights into hemophagocytic lymphohistiocytosis

Published in Virus Weekly, October 6th, 2009

"X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency affecting similar to 1 to 3 per million live male births. are generally healthy until facing a viral infection such as Epstein-Barr Virus and then may develop fulminant infectious mononucleosis and die," investigators in the United States report.

"XLP patients are also at increased risk of hemophagocytic lymphohistiocytosis (HLH), which may be triggered by assorted viruses. Here we report a novel case of HLH in a patient with XLP. Significant to his presentation is a paradoxical increase in natural killer (NK) cell activity. We hypothesize that this indicates that Parvovirus B19 activates NK cells...

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Source: Virus Weekly (2009-10-06)

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