Antivirals
Reports from University of Southern California, Department of Chemistry add new data to research in antivirals
Published in Virus Weekly, May 18th, 2010
A new study, 'Modifications to the dNTP triphosphate moiety: from mechanistic probes for DNA polymerases to antiviral and anti-cancer drug design,' is now available. According to recent research from the United States, "Abnormal replication of DNA is associated with many important human diseases, most notably viral infections and neoplasms. Existing approaches to chemotherapeutics for diseases associated with dysfunctional DNA replication classically involve nucleoside analogues that inhibit polymerase activity due to modification in the nucleobase and/or ribose moieties."
"These compounds must undergo multiple phosphorylation steps in vivo, converting them into...
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Source: Virus Weekly (2010-05-18)
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