Papillomavirus
Data from N.S. Banerjee and Colleagues Advance Knowledge in Papillomavirus
Published in Virus Weekly, June 14th, 2011
2011 JUN 14 -- "The productive program of human papillomaviruses occurs in differentiated squamous keratinocytes. We have previously shown that HPV-18 DNA amplification initiates in spinous cells in organotypic cultures of primary human keratinocytes during prolonged G(2) phase, as signified by abundant cytoplasmic cyclin B1 (Wang, H. K., Duffy, A. A., Broker, T. R., and Chow, L. T. (2009) Genes Dev. 23, 181-194)," investigators in Birmingham, United States report.
"In this study, we demonstrated that the E7 protein, which induces S phase reentry in suprabasal cells by destabilizing the p130 pocket protein (Genovese, N. J., Banerjee, N. S., Broker, T. R.,...
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Source: Virus Weekly (2011-06-14)
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