Epstein-Barr Virus

Data on Epstein-Barr Virus Discussed by Researchers at University of Wisconsin

Published in Virus Weekly, June 14th, 2011

2011 JUN 14 -- According to a study from Madison, United States, "The Epstein-Barr virus (EBV) BZLF1 gene encodes the immediate-early (IE) protein Zta, which plays a central role in regulating the switch between viral latency and lytic replication. A silencing element, ZIIR, is located between the ZID and ZII positive regulatory elements in the BZLF1 promoter Zp."

"We report here the phenotypes of variants of EBV strain B95.8 containing base substitution mutations in this ZIIR element. HEK293 cells infected with ZIIR mutant (ZIIRmt) virus produced at least 20-fold more viral IE Zta and Rta and early (E) EAD protein than did cells infected with the parental...

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Source: Virus Weekly (2011-06-14)

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