Cytomegalovirus

Researchers at Virginia Commonwealth University Release New Data on Cytomegalovirus

Published in Virus Weekly, June 14th, 2011

2011 JUN 14 -- "Herpesvirus DNA replication proceeds via concatemeric replicative intermediates that are comprised of head-to-tail linked genomes. Genome maturation is carried out by the terminase, an enzyme complex that mediates both the insertion of concatemer DNA into capsids and its subsequent cleavage to release genomes within these capsids," scientists in Richmond, United States report.

"This cleavage is sequence specific, but the governing cis-acting DNA sequences are only partially characterized. Two highly conserved motifs, the pac1 and pac2 motifs, lie near the ends of herpesvirus genomes and are known to be critical for genome maturation. In...

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Source: Virus Weekly (2011-06-14)

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