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Herpes Simplex Virus

New Herpes Simplex Virus Study Results from Hannover School of Medicine Described

Published in Virus Weekly, June 14th, 2011

2011 JUN 14 -- "Incoming capsids of herpes simplex virus type 1 (HSV-1) enter the cytosol by fusion of the viral envelopes with host cell membranes and use microtubules and microtubule motors for transport to the nucleus. Upon docking to the nuclear pores, capsids release their genomes into the nucleoplasm," scientists in Hannover, Germany report.

"Progeny genomes are replicated in the nucleoplasm and subsequently packaged into newly assembled capsids. The minor capsid protein pUL25 of alphaherpesviruses is required for capsid stabilization after genome packaging and for nuclear targeting of incoming genomes. Here, we show that HSV-1 pUL25 bound to mature...

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