Papillomavirus

Findings from V. Muto and Co-Researchers Advance Knowledge in Papillomavirus

Published in Virus Weekly, June 14th, 2011

2011 JUN 14 -- According to recent research from Rome, Italy, "Crucial steps in high-risk human papillomavirus (HR-HPV)-related carcinogenesis are the integration of HR-HPV into the host genome and loss of viral episomes. The mechanisms that promote cervical neoplastic progression are, however, not clearly understood."

"During HR-HPV infection, the HPV E5 protein is expressed in precancerous stages but not after viral integration. Given that it has been reported that loss of HPV16 episomes and cervical tumor progression are associated with increased expression of antiviral genes that are inducible by type I interferon (IFN), we asked whether E5, expressed...

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Source: Virus Weekly (2011-06-14)

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