Published in Women's Health Law Weekly, June 27th, 2004
Most studies of estrogen's ability to promote breast tumor growth have focused on mechanisms that increase tumor proliferation, but estrogen may also play a role in the regulation of angiogenesis, or blood vessel formation, suggest Hynda K. Kleinman, PhD, of the NIH's National Institute of Dental and Craniofacial Research, and colleagues.
Vascular endothelial growth factor (VEGF) and its two receptors, VEGFR-1 and VEGFR-2, play a regulatory role in angiogenesis. "VEGFR-2 is a positive angiogenic...
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