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U.S. National Institutes of Health

Possible new mechanism suggested for estrogen's promotion of disease

Published in Women's Health Law Weekly, June 27th, 2004

A study by U.S. National Institutes of Health (NIH) scientists shows how estrogen may act as an angiogenic switch and allow progression of breast carcinoma.

Most studies of estrogen's ability to promote breast tumor growth have focused on mechanisms that increase tumor proliferation, but estrogen may also play a role in the regulation of angiogenesis, or blood vessel formation, suggest Hynda K. Kleinman, PhD, of the NIH's National Institute of Dental and Craniofacial Research, and colleagues.

Vascular endothelial growth factor (VEGF) and its two receptors, VEGFR-1 and VEGFR-2, play a regulatory role in angiogenesis. "VEGFR-2 is a positive angiogenic...

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