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Hokkaido University

Aberrant HOX gene expression related to breast cancer development

Published in Women's Health Law Weekly, June 5th, 2005

Aberrant HOX gene expression is related to breast cancer development.

"HOX genes are known not only as master genes that control the morphogenesis, but also as regulator genes that maintain tissue or organ specificity in the adult body.

"We hypothesized that dysregulated expression of HOX genes was associated with tumor development and malignant progression such as invasion and metastasis," scientists in Japan report.

"In this study, we analyzed the expression patterns of 39 HOX genes in human invasive ductal breast cancer tissues and normal tissues by the real-time RT-PCR method.

"We found 11. HOX genes...

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