University of Michigan
CD144 is transiently expressed by fetal liver hematopoietic stem cells
Published in Women's Health Law Weekly, September 25th, 2005
According to recent research published in the journal Blood, "Hematopoietic stem cells (HSCs) and endothelial progenitors arise from a common embryonic precursor. However, these populations diverge prior to the onset of definitive hematopoiesis, as HSCs become CD45+ and are thought to lose the expression of endothelial markers."
"After the onset of definitive hematopoiesis, CD144 (vascular endothelial [VE]-cadherin) has been considered a specific marker of endothelial cells. In contrast, we found that virtually all HSC activity from embryonic day 13.5 (E13.5) fetal liver...
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